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Vol 20, No 1 - HT and the Timing Hypothesis
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1.
Genistein and tamoxifen are similar in that both are considered to be:
a. Aromatase inhibitors
b. Selective estrogen receptor modulators
c. Breast cancer drugs
d. Estrogen-sensitive human breast cancer cells
2.
Letrozole and anastrozole function as:
a. Aromatase inhibitors
b. Selective estrogen receptor modulators
c. Breast cancer drugs
d. Estrogen-sensitive human breast cancer cells
3.
Clinical studies demonstrate that both estrogen and isoflavones improve:
a. Bone mineral density
b. Vaginal maturation
c. Estrogenicity
d. Endothelial function
4.
Twenty-five grams of soy protein contain how many milligrams of isoflavones:
a. 39
b. 69
c. 99
d. 109
5.
The WISH study indicated progression of carotid intima-media thickness (CIMT) in women consuming soy protein was what percentage lower than the milk protein group:
a. 10
b. 16
c. 21
d. 30
6.
Subgroup results of the WISH study showed women who were fewer then 5 years post-menopausal had CIMT progression reduced by what percentage:
a. 9
b. 17
c. 49
d. 68
7.
In the WISH study the effective dose of isoflavones would be found in how many servings of traditional soyfoods:
a. 4
b. 6
c. 8
d. 10
8.
Observational studies have shown postmenopausal hormone therapy (HT) is associated with what percent reduction in coronary heart disease (CHD):
a. 5-15
b. 15-25
c. 30-50
d. 55-70
9.
What is the percent reduction in overall mortality in women who initiate HT in close proximity to menopause:
a. 15
b. 25
c. 35
d. 45
10.
The increase in quality-adjusted life-years (QALY) in younger women (in their 50s) initiating HT is:
a. 5.0
b. 2.0
c. 1.5
d. 3.5
11.
The "window of opportunity" for maximal expression of HT beneficial effects on CHD and overall mortality while minimizing risk appears to occur with HT initiation
prior to what age:
a. 55
b. 60
c. 65
d. 70
12.
The "window of opportunity" for maximal expression of HT beneficial effects on CHD and overall mortality while minimizing risk appears to occur with HT initiation
within how many years of menopause:
a. 5
b. 6
c. 10
d. 12
13.
The "window of opportunity" for maximal expression of HT beneficial effects on CHD and overall mortality while minimizing risk appears to occur with HT initiation
continued for how many years or more:
a. 2
b. 3
c. 5
d. 6